在第十任博士的故事里,他始终强烈的孤独。仿佛诅咒,他的同伴——所有的人总有一天离开他;自己并一个人地走向死亡。在他的生命最终结束的时候,坐着塔迪斯和过去的同伴一一告别。第十任是一个轻松健谈,随和机智的人,对敌人总会给予第二次机会却又绝不过分仁慈。曾经和女伴罗斯有过一场恋爱,最后以两人分隔在不同的宇宙告终,之后也和其它的同伴一起环游宇宙,拯救世界。第十任一般穿深褐色(蓝色条纹)或蓝色(铁锈红条纹)四个扣子的西装,衬衫和领带,浅棕色的人造麂皮大衣。Independently of one another, the Doctor and Donna Noble are investigating Adipose Industries who claim to have created a revolutionary diet pill. The head of Adipose, Miss Foster, runs a pretty tight ship and they have been quite successful. Donna visits several people who have taken the pills and as advertised, the pills seem to be working. Except of course for the person that virtually vanishes, excerpt for a strange little creature in the bathroom sink. The Doctor and Donna join up eventually and come to the realization that there is definitely something alien behind what is going on.